Blister - package integrity - ASTM F2338-09 - USP <1207> - GMP - CCIT - Container Closure Integrity Testing


Brand: PTI
Product: VERIPAC 410


The VeriPac 410 inspection system offers non-destructive seal and leak detection for blister packs, sachets, and pouches with low headspace.

Multi-cavity blister packs and low head space packaging use a variety of test methods to determine package integrity, with most being destructive, subjective, and unreliable.

The VeriPac 410 utilizes a combination of vacuum decay technology and differential force measurement to identify defective packages. Multiple packages can be tested in a single test cycle, and the 410 identifies which package or cavity is defective. Test results are quantitative and provide operators with a definitive pass/fail, eliminating the subjective and destructive nature of current test methods.

Package quality assurance is achieved by deploying accurate, reliable non-destructive inspection methods, removing subjectivity from the testing process while reducing waste. The VeriPac 410 allows tested product to be returned to the production line and eliminates the significant costs and waste associated with destructive leak test methods.


- Non-destructive, non-invasive, no sample preparation
- Accurate and repeatable results
- Test multiple packages in a single test cycle
- Identifies which package is defective
- Simplifies the inspection and validation process
- Supports sustainable packaging initiatives
- ASTM test method and FDA standard
- Cost effective with rapid return on investment


The VeriPac 410 tester is connected to a specially designed drawer-style test chamber.
A custom package insert that conforms to the package shape increases test sensitivity.
Multiple packages can be tested in a single test cycle, and the location of the defective package or cavity is identified.
Vacuum levels are monitored during the test cycle to evaluate the package using the ASTM F2338 vacuum decay leak test method.
Decay of the vacuum level indicates that air is leaking from the package into the test chamber.

Once the vacuum testing phase is complete, a pressure plate maps the surface pressure of the flexible package lidding.
The pressure plate system recognizes the pressure pattern exerted by the package when it is not defective, and the lack of pressure exerted on the pressure plate by a defect, allowing for both defect detection and location of the defective package or cavity.

Inspection Criteria

- Leak detection and seal integrity testing of entire package
- Test sensitivity down to 15 microns

VeriPac 410


- Non-destructive leak detection of blister packs, sachets and pouches with low headspace with defect profile typically >15 microns

Package Type

- Blister packs
- Sachets
- Pouches with low headspace

Package Materials

- Non-porous materials: foil, plastic, poly, film, Aluminum, paper

Test Method*

- Absolute vacuum transducer
- Pressure plate


- Vacuum decay and differential force measurement

Operator Interface

- 10" color touch screen

Test Parameter Storage

- Up to 50 packages

Test Result Data

- Pass/Fail Result in mBar units

Test Sensitivity

- 2 ccm (approximate hole size 15 microns)

Security Password

- Yes

Remote Internet Access

- Yes

Data Collection

- View on touch screen and electronic data log collection

Test Chamber

- Test drawer configuration

ASTM Test Method

- ASTM F2338-09**


- Microcalibrator flowmeter
- Validation package (IQ/OQ/PQ)